Researchers of Herbert Irving Comprehensive Cancer Center and the Columbia Initiative in Systems Biology have discovered two genes that appear to work together as master switches to turn on hundreds of other genes that drive the most aggressive forms of brain cancer: they hope their findings will help develop new approaches to treat these incurable tumors. These are the findings of a study published in the advanced online issue of the journal Nature.

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Roche Holding AG said cancer drug Avastin could play an important role in improving the daily lives of patients with the most aggressive form of brain cancer. An analysis of the phase II BRAIN study of Avastin alone or in combination with irinotecan chemotherapy for the treatment of relapsed or progressive glioblastoma demonstrated that the six months Avastin-based therapy improved patients’ chances of remaining alive without worsening their disease and had additional positive impact on patients.