Pro-Pharmaceuticals Inc., on the 30th of August, 2008, announced that the U.S. Food and Drug Administration (FDA) has granted an Investigational New Drug (IND) application for use of DAVANAT® in combination with 5-FU to treat a patient of breast cancer at the Brown Cancer Center in Louisville, Kentucky. Also, DAVANAT is being administered in Phase II clinical trials for first-line treatment of colorectal and biliary cancer patients. Studies showed that DAVANAT®, when given along with chemotherapy, reduced tumor growth and toxicity considerably in mice implanted with metastatic human breast cancer. It also lowered the levels of side effects.